S6B-3 Intracerebroventricular Streptozocin-Induced Alzheimer’s Disease-Like Sleep Disord

S6B-3 Intracerebroventricular Streptozocin-Induced Alzheimer’s Disease-Like Sleep Disorders:Role of the GABAergic System in the

Parabrachial Complex

CUI Su-ying; SONG Jin-zhi; CUI Xiang-yu; HU Xiao; DING Hui; YE Hui; ZHANG Yong-he

【期刊名称】《《神经药理学报》》 【年(卷),期】2018(008)004

【摘要】Aim:Sleep disorders are common in Alzheimer’s disease(AD)and assumed to directly influence cognitive function and progression of the disease.The present study evaluated sleep characteristics in a rat model of AD that was induced by intracerebroventricular administration of streptozocin,and we assessed the possible underlying mechanisms.Methods:The cognition ability of rats was assessed by Morris water maze(MWM)trails.Sleep parameters were

analyzed

by

electroencephalographic(EEG)and

electromyographic(EMG)recordings.The neuronal activity in sleep-wake regulating

brain

areas

was

evaluated

by

double-staining

immunohistochemistry test.High performance liquid chromatograph-electrochemical detection(HPLC-ECD)was used for the detection of neurotransmitters.Results:On day 14 after STZ injection,the rats exhibited sleep disorders that are similar to those in AD patients as evidenced by significant increase in wakefulness and decrease in rapid-