Rationale and Study Design for a Single-Arm Phase Iia Study Investigating Feasibility of P

Rationale and Study Design for a Single-Arm Phase Iia Study Investigating Feasibility of Preventing Ischemic Cerebrovascular Events in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events Using Remote Ischemic

Conditioning

Shi-Meng Liu;Wen-Le Zhao;Hai-Qing Song;Ran Meng;Si-Jie Li;Chang-Hong Ren;Bruce Ovbiagele;Xun-Ming Ji;Wu-Wei Feng

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2024(131)003

【摘要】Background:Acute minor ischemic stroke (AMIS) or transient ischemic attack (TIA) is a common cerebrovascular event with a considerable

high

recurrence.Prior

research

demonstrated

the

effectiveness of regular long-term remote ischemic conditioning (RIC) in secondary stroke prevention in patients with intracranial stenosis.We hypothesized that RIC can serve as an effective adjunctive therapy to pharmacotherapy in preventing ischemic events in patients with AMIS/TIA.This study aimed to investigate the feasibility,safety,and preliminary

efficacy

of

daily

RIC

in

inhibiting

cerebrovascular/cardiovascular events after AMIS/TIA.Methods:This is a single-arm,open-label,multicenter Phase IIa futility study with a sample size of 165.Patients with AMIS/TIA receive RIC as an additional therapy