利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用

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梁冰;梁启德;张凤玲;江坤洪;黎意芬;曹满霞

【期刊名称】《实用医学杂志》【年(卷),期】2017(033)006

【摘要】目的:探讨利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用.方法:选取我院2013年1月至2015年12月的复治涂阳肺结核患者100例,随机将含利福平为对照组,同时含利福平和左氧氟沙星为研究组各50例,观察两组患者服药0.5、1、2 h后的RFP血药浓度,痰涂片及随访时间为治疗2、5、8、9月末;从而分析利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用.结果:患者在服药0.5、1、2 h后研究组和对照组之间的利福平血药浓度波动不明显,差异没有统计学意义(P>0.05);随着治疗时间的延长,患者的痰涂阳性逐渐降低,而且治疗2、5、8、9月末两组患者的痰涂阳性率差异存在统计学意义(P<0.05);治疗8个月后两组患者的稳定和治疗中的比例差异存在统计学意义(P<0.05).结论:利福平与左氧氟沙星在复治涂阳肺结核治疗中不存在拮抗作用,利福平与左氧氟沙星可以联合用于复治涂阳肺结核治疗.%Objective To investigate

the

interaction retreatment

between smear

rifampin(RFP)and positive

pulmonary

levofloxacin(LVFX)in

tuberculosis(TB). Methods One hundred retreated smear positive TB patients admitted to our hospital between January 2013 and December 2015 were randomly divided into two groups:the control group in 50 patients with only RFP treatment,and the treatment group in 50 patients with both RFP and LVFX treatments. The RFP plasma concentration was

tested 0.5 h,1 h,and 2 h after intake of medicine. Sputum smear test was performed at the end of February,May,August and September to investigate the interaction between RFP and LVFX in retreatment of smear positive TB. Results The plasma concentration of RFP did not show significant difference(P > 0.05)between the control group and the treatment group at 0.5 h,1 h,and 2 h after intake of medicine. As the treatment time went on,the level of smear positive gradually decreased. The sputum smear positive rate after 2,5,8,and 9 months of treatment showed significant difference between the control group and the treatment group. After 8 months of treatment,the ratio of stabilized patients and patients under treatment also showed significant difference(P<0.05). Conclusion Rifampicin and levofloxacin have no antagonism effect in retreatment of smear positive TB,and RFP and LVFX can be used together to treat the repeated smear positive TB. 【总页数】4页(967-970)

【关键词】肺结核;复治涂阳;利福平;左氧氟沙星;相互作用【作者】梁冰;梁启德;张凤玲;江坤洪;黎意芬;曹满霞

【作者单位】510095 广州市胸科医院第二门诊;510095 广州市胸科医院第二门诊;510095 广州市胸科医院第二门诊;510095 广州市胸科医院第二门诊;510095 广州市胸科医院第二门诊;510095 广州市胸科医院第二门诊【正文语种】中文【中图分类】

【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_journal-practical-medicine_thesis/0201250178043.html 【相关文献】

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