Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in is

Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone Ⅰ

Joon Ha Park;Ok kyu Park;Yan Bingchun;Ji Hyeon Ahn;In Hye Kim;Jae-Chul Lee;Seung-Hae Kwon

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2014(127)019

【摘要】Background Danshen (Radix Salvia miltiorrhizae) has been used as a traditional medicine in Asia for treatment of various microcirculatory disturbance related diseases.Tanshinones are mainly hydrophobic active components,which have been isolated from Danshen and show various biological functions.In this study,we observed the neuroprotective effect of tanshinone Ⅰ (Tsl) against ischemic damage in the gerbil hippocampal CA1 region (CA1) after transient cerebral ischemia and examined its neuroprotective mechanism.Methods The gerbils were divided into vehicle-treated-sham-group,vehicle-treated-ischemia-group,Tsl-treated-shamgroup,and Tsl-treated-ischemia-group.Tsl was administrated intraperitoneally three times (once a day for three days) before ischemia-reperfusion.The neuroprotective effect of Tsl was examined using H&E staining,neuronal nuclei (NeuN) immunohistochemistry and Fluoro-Jade B staining.To investigate

the

neuroprotective

mechanism

of

Tsl

after