Ischemic postconditioning alleviates lung injury and maintains a better expression of aqua

Ischemic postconditioning alleviates lung injury and maintains a better expression of aquaporin-1

during cardiopulmonary bypass

Cheng Chi;Li Shanshan;Wang Yong;Chen Song;You Lu;Zhang Hong

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2014(000)023

【摘要】Background It has found that ischemic postconditioning (IPO) might decrease pulmonary ischemia/reperfusion (I/ R) injury,which is one of the main reasons of lung injury caused by cardiopulmonary bypass (CPB).It was found that aquaporins (AQPs) play a role in the maintenance of fluid homeostasis.But it is still unclear whether IPO influences the expression of aquaporin-1 (AQP1).This study was designed to investigate whether IPO can reduce CPB-related lung injury and affect the expression of AQP1 of lungs.Methods Twelve healthy dogs were divided into control group (C group) and ischemia postconditioning

group

(IPO

group).CPB

procedures

were

implemented.Ten minutes later,the left pulmonary artery was separated and blocked.Postconditioning consisted of two cycles of 5-minute pulmonary artery reperfusion/5-minute reocclusion starting at the beginning of reperfusion.The 2×4 cm tissues of both sides of pulmonary apex,superior,middle and inferior lobe were taken before CPB (T1),before occlusion and reopening of left pulmonary artery