波生坦联合伐地那非治疗先天性心脏病术后肺动脉高压的
疗效观察
江昆
【期刊名称】《现代药物与临床》 【年(卷),期】2016(031)006
【摘要】Objective To explore the clinical effect of bosentan combined with vardenafil in treatment of pulmonary arterial hypertension after congenital heart disease operation. Methods Patients (76 cases) with pulmonary arterial hypertension after congenital heart disease operation in Department of Cardiothoracic Surgery, the Second People’s Hospital of Liaocheng from January 2013 to January 2015 were randomly divided into the control and treatment groups, and each group had 38 cases. Patients in the control group were po administered with Vardenafil Hydrochloride Tablets, 20 mg/time, once daily. Patients in the treatment group were po Bosentan Tablets on the basis of the control group, body weight<10 kg:15.625 mg/time, body weight 10 — 20 kg:31.25 mg/time, body weight 21 — 40 kg:62.5 mg/time, once daily. Patients in two groups were treated for 6 months. After treatment, the efficacy was evaluated, and the changes of Borg scores, BNP, NYHAFC, SpO2, 6 MWTD, and right heart catheterization results in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were73.68%and 92.11%,
波生坦联合伐地那非治疗先天性心脏病术后肺动脉高压的疗效观察
