GROWTH DIFFERENTIATION FACTOR-5 STIMULATES THE GROWTH AND ANABOLIC METABOLISM OF ARTICULAR

GROWTH DIFFERENTIATION FACTOR-5 STIMULATES THE GROWTH AND ANABOLIC METABOLISM OF ARTICULAR CHONDROCYTES

许鹏;郭雄;张银刚;Jung;Park;Klaus;von;der;Mark

【期刊名称】《药物分析学报：英文版》 【年(卷),期】2005(000)002

【摘要】Growthdifferentiationfactor5(GDF5),also knownascartilage derivedmorphogeneticprotein1(CDMP1),isamemberofthebonemorphogenet

icprotein(BMP)familywhichbelongstothe

transforminggrowthfactorβ(TGFβ)superfami ly[1].GDF5isarelativelynewmemberofthe BMPfamily.LikeotherBMPs,implantationofre combinantGDF5caninduceectopiccartilagefor mationinmusculartissues.Thephysiologicalrole ofGDF5hasbeenreportedincludingregulationof myogenesis,regulationofchondrogenesis,bone

morphogenesis,andneurondifferentiationandsur vival[2].GDF5... 【总页数】5页(P.94-98) 【关键词】

【作者】许鹏;郭雄;张银刚;Jung;Park;Klaus;von;der;Mark 【

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of;Endemic;Diseases;Laboratory;of;Environment;and;Genes;Related;to;Di