MicroRNA在肝癌干细胞中的作用研究进展

MicroRNA在肝癌干细胞中的作用研究进展

牛连杰;张雅敏

【期刊名称】《中华肝胆外科杂志》 【年(卷),期】2024(024)009

【摘要】Liver cancer stem cells have the abilities of infinite proliferation,self-renewal,chemoradiation tolerance,high tumorigenicity and stem cell characteristics.The proportion of liver cancer stem cells is positively correlated with the malignancy of the tumor.MicroRNAs (miRNA) can regulate the expression of many genes by degrading mRNA or inhibiting mRNA translation.MicroRNAs also play an important role in a series of life activities such as embryogenesis,tissue and

organ

development,cell

growth

and

differentiation,apoptosis,disease development.In-depth study of specific miRNA in the occurrence and development of liver cancer and its role in LCSCs,it may provide a new target for prevention and treatment of recurrence and metastasis of liver cancer.%肝癌干细胞(LCSCs)不但具有无限增殖、自我更新、放化疗耐受以及高致瘤能力,并具有干细胞特性.其比例与肿瘤的恶性程度呈正相关.microRNA (miRNA)可通过降解mRNA或抑制mRNA翻译调控众多基因的表达,在胚胎发生、组织器官发育、细胞生长分化与凋亡、疾病发生发展以及LCSCs的维持等一系列生命活动中发挥着重要作用.深入研究特定miRNA在肝癌发生、发展以及在LCSCs中的作用,可为防治肝癌的复发和转移提供新靶点.