肝癌基因治疗的机遇和挑战
钱程;沈俊杰;单娟娟
【期刊名称】《中华消化外科杂志》 【年(卷),期】2010(009)001
【摘要】Gene therapy has emerged as an efficient modality to treat human diseases.This method is based on the transfer of genetic material to tissues to induce a curative effect.Gene therapy vectors are molecular constructs used to facilitate the penetration of genomic sequences inside the cells.Viral vectots have however several limitations when administered directly to the patient.They may cause significant toxicity by activating innate immunity or by eliciting an adaptive immune response against viral proteins.In addition,targeting the vector to the desired site is an issue when given systemically.The use of cells as vehicles for gene therapy vectors has many advantages.The combination of cell-viro-gene therapy has been thought as a new and promising strategy for therapy of cancer.The targeting vector to cancer stem cells will become a new direction in the field of gene therapy.In this article,we will introduce progressions,limitations and future directions of gene therapy of liver cancer. 【总页数】3页(12-14) 【关键词】肝肿瘤;基因治疗 【作者】钱程;沈俊杰;单娟娟
【作者单位】400038,重庆,第三军医大学西南医院病理学研究所生物治疗研究室;400038,重庆,第三军医大学西南医院病理学研究所生物治疗研究室;400038,重庆,第三军医大学西南医院病理学研究所生物治疗研究室 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-digestive-surgery_thesis/0201233846917.html 【相关文献】
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肝癌基因治疗的机遇和挑战
