多西他赛联合顺铂方案治疗局部晚期鼻咽癌的疗效和预后分析

多西他赛联合顺铂方案治疗局部晚期鼻咽癌的疗效和预后

分析

刘子莹;金风;吴伟莉;陈海霞;栗惠芹

【期刊名称】《中国药房》 【年(卷),期】2011(022)008

【摘要】目的:分析多西他赛(TXT)+顺铂(DDP)方案联合放疗治疗局部晚期鼻咽癌的疗效和预后情况.方法:选择2003年1月-2006年12月收治的初治局部晚期鼻咽癌患者59例,观察TXT+DDP联合放疗治疗局部晚期鼻咽癌的疗效、预后及其影响因素,计算生存率及局部控制率.结果:59例患者,5年生存率、无复发生存率、无转移生存率分别为72%、82%和54%.与总生存率有关的因素有T分期、N分期、92福州分期、年龄、治疗前贫血、KPS评分,与无复发生存率有关的因素有T分期、贫血、KPS评分.结论:TXT+DDP诱导化疗及同期放/化疗加辅助化疗治疗局部晚期鼻咽癌,远期生存率好,5年无复发生存率及5年无远转生存率有较大的提高且毒副反应轻.早期发现患者,治疗前改善一般状况及纠正贫血有助提高生存率.%OBJECTIVE: To analyze the therapeutic efficacy and prognosis of chemotherapy of docetaxel(TXT) and cisplatin (DDP) combined with radiotherapy for local advanced nasopharyngeal carcinoma (NPC). METHODS: From Jan. 2003 to Dec.2006, 59 newly diagnosed patients with local advanced NPC were treated with chemotherapy of TXT+DDP combined radiotherapy.The therapeutic efficacy, prognosis and influencing factors were observed. Survival rate and local control rate were calculated using Kaplan-Meier method, and

the difference test was conducted by Cox proportion risk model. RESULTS: The 5-year overall survival rate and relapse-free survival rate and metastasis-free survival rate were 72％, 82％ and 54％, respectively. T stage and N stage,92 Fuzhou stage, age, pretreatment hemoglobin level, KPS score were all associated with overall survival rate. T stage, pretreatment hemoglobin level and KPS score were related to relapse-free survival rate. CONCLUSION: The chemotherapy of TXT+DDP combined with radiotherapy in the treatment of local advanced NPC are promised. Long-term survival rate, 5-year relapse-free survival rate and metastasis-free survival rate have been improved significantly. There are mild toxic reactions. Early diagnosis and treatment, pretreatment relief and anaemia correction can improve survival rate significantly. 【总页数】4页(705-708)

【关键词】多西他赛;顺铂;鼻咽癌;预后 【作者】刘子莹;金风;吴伟莉;陈海霞;栗惠芹

【作者单位】贵州省肿瘤医院,贵阳市,550003;贵州省肿瘤医院,贵阳市,550003;贵州省肿瘤医院,贵阳市,550003;贵州省肿瘤医院,贵阳市,550003;贵州省肿瘤医院,贵阳市,550003 【正文语种】中文 【中图分类】R739.62 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_china-

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