Antioxidant, phytotoxic and cytotoxic activity of methanolic extract ofTrigonella foenum-graecum

Antioxidant, phytotoxic and cytotoxic activity of methanolic extract ofTrigonella foenum-graecum

Amin

Ullah;Said

Hassan;Muhammad

Imran

Khan;Muhammad

Rizwan;Zafar

Ullah;Mukaram Shah

【期刊名称】《海岸生命医学杂志（英文版）》 【年(卷),期】2016(004)005

【摘要】Objective:To analyze the methanol extract ofTrigonella foenum-graecum(T. foenum-graecum) for antioxidant, phytotoxic and cytotoxic activity.
Methods: The powder ofT. foenum-graecum was extracted in diluted methanol with the help of random shaking method. All extracts of the plant were measured for cytotoxic activity (beside brine shrimp and antioxidant activityvs. 1, 1-diphenyl-2-picrylhydrazyl free radical).
Results: Various concentrations of methanolic extract ofT. foenum-graecumwere observed as 36.16% to 54.12% with rising concentrations of 50 to 1 000μg/mL. Significantly phytotoxic activity (100 and 1 000μg/mL) reduced the growth of roots (radicals) and shoots (hypocotyls) of rice when compared to control after 3 and 7 days’ treatment. At a concentration of 10μg/mL, the survival rate of cytotoxic activity of brine shrimp was maximum and at a concentration of 250μg/mL, the death rate of brine shrimp was maximum.
Conclusions:T. foenum-graecum has potential activity against free radical mediated sickness and thus it is possible to treat cancer.