人工寒潮对易卒中型肾血管性高血压大鼠凝血和纤溶系统
的变化研究
祁玉凤;李常新;吴晓巍;王慧芳;翟俊格;高润兰
【期刊名称】《中西医结合心脑血管病杂志》 【年(卷),期】2011(009)004
【摘要】Objective To study the effect of artificial cold stream on coagulation and fibrinolysis in rats with stroke - prone renovascular hypertension. Methods The models with stroke - prone renovascular hypertension were established by two - kidney - two clip. The content of P- selection, fibrinopeptides A, and D- dimer were measured by enzyme- linked immunosorbant assay before and after the cold stream. Results The contents of plasma P - selection, fibrinopeptides A and D - dimer were increased gradually at 8th week after operation, and they vere different significantly compared with that in sham operation group(P＜0.05). The levels of these factors were the highest at 3 h in artificial cold stream and decreased gradually at 6 h, 12 h. They were different significantly compared with non - cold stream group(P＜0.05). Conclusion Up - regulative activity of coagulation and fibrinolysis after artificial cold stream might play a role in the onset of cerebral infarction, cerebral hemorrhage, and mixed stroke.%目的 观察寒潮时易卒中型肾血管性高血压大鼠(RHRSP)血液中凝血和纤溶系统的活性改变.方法 双肾双夹法制作RHRSP模型,分别于寒潮前后取血,酶联免疫吸附测定(ELISA)法检测P-选择素
人工寒潮对易卒中型肾血管性高血压大鼠凝血和纤溶系统的变化研究
