Ubiquitin at the crossroad of cell death and
survival
Yu-Shan Chen;Xiao-Bo Qiu
【期刊名称】《癌症（英文版）》 【年(卷),期】2013(000)012
【摘要】Ubiquitination is crucial for cellular processes, such as protein degradation, apoptosis, autophagy, and cell cycle progression. Dysregulation of the ubiquitination network accounts for the development of numerous diseases, including cancer. Thus, targeting ubiquitination is a promising strategy in cancer therapy. Both apoptosis and autophagy are involved in tumorigenesis and response to cancer therapy. Although both are categorized as types of celldeath, autophagy is general y considered to have protective functions, including protecting cells from apoptosis under certain cellular stress conditions. This review highlights recent advances in understanding the regulation of apoptosis and autophagy by ubiquitination. 【总页数】8页(640-647) 【关键词】
【作者】Yu-Shan Chen;Xiao-Bo Qiu
【作者单位】Key Laboratory of Cel Proliferation and Regulation Biology, Ministry of Education, and college of Life Sciences, Beijing Normal University, Beijing 100875, P. R. China;Key Laboratory of Cel Proliferation
and Regulation Biology, Ministry of Education, and college of Life Sciences, Beijing Normal University, Beijing 100875, P. R. China 【正文语种】英文 【中图分类】 【相关文献】
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Ubiquitin at the crossroad of cell death and survival
