Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and s

Programmed cell death 5 correlates with disease activity and interleukin-17 in serum and synovial

fluid of rheumatoid arthritis patients

WANG Jun-feng;GUAN Zhen-peng;ZHANG Shao-long;PEI Zheng;CHEN Ying-yu;PAN Huan

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)002

【摘要】Background Programmed cell death 5 (PDCD5) is a novel apoptotic regulatory gene that promotes apoptosis in various tumor cells.Studies have shown that PDCD5 accelerates the apoptosis of synoviocytes in vitro,implying a potential role in rheumatoid arthritis (RA) pathogenesis.This study examined the expression of PDCD5 in serum and synovial fluid of RA patients,its effect on the expression of inflammatory cytokine,interleukin-17 (IL-17),and the assessment of disease activity in RA.Methods PDCD5 and IL-17 levels in serum and synovial fluid from 18 patients with RA and 22 patients with osteoarthritis (OA) were detected using enzyme-linked immunosorbent assay (ELISA).Concentrations of serum PDCD5 in 40 healthy people were also detected as controls.As disease activity indices,C-reactive protein (CRP),erythrocyte sedimentation rate (ESR),rheumatoid factor (RF),and X-ray grading scale were also evaluated.Results Serum and synovial fluid PDCD5 levels in RA patients were significantly higher than those in