注射用丁二磺酸腺苷蛋氨酸致呼吸困难和血压升高
杨霞;于磊;谢宇;徐珽
【期刊名称】《药物不良反应杂志》 【年(卷),期】2017(019)004
【摘要】A 64 year-old male patient with decompensated cirrhosis of liver after hepatitis B received intravenous injection of ademetionine 1,4-butanedisulfonate injection 1 000 mg and an IV infusion of magnesium isoglycyrrhizinate injection 200 mg once daily.His heart rate, respiration rate and blood pressure were 64 beats /min, 16 times/min and 100/65 mmHg, respectively.Five to six minutes after intravenous injection of ademetionine 1,4-butanedisulfonate for injection on the first day, the patient suddenly developed dyspnea, dysphoria, palpitation, lip cyanosis, wheezing, and moist rales in lungs.It was considered that the adverse reactions was induced by ademetionine 1,4-butanedisulfonate
injection.The
medication
was
withdrawn
immediately.Bedside ECG monitoring showed that his heart rate, blood pressure and pulse oxygen saturation (SpO2) were 123 beats/min, 224/141 mmHg, and 0.8-0.9, respectively.The patient received mask oxygen inhalation, inhalation of bricalin and budesonide, intravenous injection of dexamethasone sodium phosphate injection 5 mg, an IV infusion of methylprednisolone 40 mg, and doxofylline and glucose for injection 300 mg.About 30 minutes later, the patient′s dyspnea was
improved.His heart rate decreased to 76 beats/min, blood pressure declined to 114/62 mmHg, and SpO2 returned to 0.99.The patient was ordered to be kept in bed and received nasal oxygen inhalation.The nasal oxygen was stopped on the third day and intravenous injection of magnesium isoglycyrrhizinate was given.The patient did not develop the symptoms mentioned above.%1例64岁男性患者,因乙型肝炎后肝硬化失代偿期,静脉注射丁二磺酸腺苷蛋氨酸1 000 mg和静脉滴注异甘草酸镁200 mg,1次/d.患者用药前心率64次/min,呼吸16次/min,血压100/65 mmHg(1 mmHg=0.133 kPa).第1天静脉注射丁二磺酸腺苷蛋氨酸5~6min后,患者出现突发呼吸困难、烦躁不安、心慌、口唇紫绀、双肺散在哮鸣音及湿罗音,考虑可能为丁二磺酸腺苷蛋氨酸引起的不良反应,停用该药.床旁心电监护示心率123次/min,血压224/141 mmHg,SpO2 0.8~0.9,予以面罩加压吸氧,硫酸特布他林及布地奈德液雾化吸入,地塞米松磷酸钠注射液5 mg静脉注射,甲泼尼龙琥珀酸钠40 mg静脉滴注,多索茶碱葡萄糖注射液300 mg静脉滴注,约30 min后患者自觉气促缓解,心率降至76次/min,血压降至114/62 mmHg,SpO2恢复至0.99,患者卧床休息并持续鼻导管吸氧.第3日停鼻导管吸氧,静脉滴注异甘草酸镁,患者未再次出现上述反应. 【总页数】2页(310-311)
【关键词】S-腺苷甲硫氨酸;呼吸困难;高血压 【作者】杨霞;于磊;谢宇;徐珽
【作者单位】610041成都,四川大学华西医院临床药学部;610041成都,四川大学华西医院临床药学部;621000 四川省绵阳市第三人民医院消化科;610041成
都,四川大学华西医院临床药学部 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_adverse-drug-reactions-journal_thesis/0201241104036.html 【相关文献】
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注射用丁二磺酸腺苷蛋氨酸致呼吸困难和血压升高
