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替米沙坦氢氯噻嗪片的溶出度研究

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替米沙坦氢氯噻嗪片的溶出度研究

郭焱

【期刊名称】《药学研究》 【年(卷),期】2014(000)012

【摘要】Objective To study the dissolution behavior of telmisartan and hydrochlorothiazide in Telmisartan and Hydrochlorothiazide Tablets in four different dissolution media. Methods According to the dissolution test conditions in Ja-pans\make choice of the dissolution medium in accordance with the physico-chemical

properties

of

Telmisartan

and

Hydrochlorothiazide

Tablets,different Telmisartan and Hydrochlorothiazide Tablets were inspected in pH 1. 2 solution(containing 0. 5% twelve sodium dodecyl sulfate),pH 4. 0 acetate buffer(containing 0. 5% twelve sodium dodecyl sulfate),pH 6. 8 phosphate buffer(containing 0. 25% twelve sodium dodecyl sulfate)and water (containing 0. 25% twelve sodium dodecyl sulfate)by HPLC,and the resemblance of release curves were compared with similarity factors( f2 )method. Results The assay displayed a good linearity over the concentration range of 20~50 μg· L-1 ,6~20 μg·L-1 for telmisartan

and

hydrochlorothiazide;In

4

different

dissolution

media,compared with telmisartan,f2 of hydrochlorothiazide was greater than 50. Conclusion The method was simple,accurate and reproducible for the dissolu-tion determination of this tablet;The dissolution of

替米沙坦氢氯噻嗪片的溶出度研究

替米沙坦氢氯噻嗪片的溶出度研究郭焱【期刊名称】《药学研究》【年(卷),期】2014(000)012【摘要】ObjectiveTostudythedissolutionbehavioroftelmisartanandhydrochlorothiazideinTelmisartanandHydrochlor
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