Inhibitory effect of three biopolymer materials on scar formation following trabeculectomy

Inhibitory effect of three biopolymer materials on

scar formation following trabeculectomy

佚名

【期刊名称】《《国际眼科杂志：英文版》》 【年(卷),期】2011(000)004

【摘要】AIM: To investigate the inhibitory effects of amniotic membrane, polylactic acid membrane and chitosan membrane on scar formation following trabeculectomy. METHODS: A total of 24 New Zealand white rabbits (48 eyes) were randomly divided into 4 groups: amniotic membrane group, polylactic acid membrane group, chitosan membrane group, and control group, with 6 rabbits (12 eyes) in each group. The left eyes underwent routine trabeculectomy, and the right eyes were considered as controls. Amniotic membrane, polylactic acid membrane and chitosan membrane were respectively installed under sclera flap in three groups, but any treatment was not applied in control group. Intraocular pressure, conjunctival filtering bleb, and anterior chamber inflammation responses were monitored at day 1, 3, 7, 14, 28 and 56 post-operatively.

Eyeball

tissue

underwent

histopathological

examination at day 56 post-operatively. RESULTS: Fibrocytes and inflammatory cells were reduced in amniotic membrane, polylactic acid membrane and chitosan membrane groups compared to that in control group. At day 1 post-operatively, intraocular pressure was decreased in

three membrane groups compared to that in control group. At day 14 post-operatively, the intraocular pressure was decreased significantly, while it of three membrane groups was significantly lower than that of preoperative (P <0.01). There were no significant differences among three membrane groups (P >0.05). Filtering bleb of four groups was clearly observed at day 7 post-operatively, but there was no significant difference in pair-wise comparison. At day 28 and 56 post-operatively, filtering bleb in control group was significantly narrowed compared to that in three membrane groups (P <0.05), but there was no significant difference in pair-wise comparison of three membrane groups. CONCLUSION: All amniotic membrane, polylactic acid membrane and chitosan membrane can effectively inhibit scar formation following trabeculectomy, the effect of amniotic membrane is the best. 【总页数】4页(P.380-383)

【关键词】amniotic membrane polylactic acid membrane chitosan membrane glaucoma filtration surgery 【作者】佚名 【作者单位】 【正文语种】中文 【中图分类】R779.6 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_international-

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