健康中老年人肺功能下降与呼吸中枢驱动变化的关系
林淑芳;巩海红;黎锐发;邱志辉;罗远明
【期刊名称】《中华老年医学杂志》 【年(卷),期】2012(031)003
【摘要】Objective To explore the relationship between reduction of lung function and neural respiratory drive in healthy middle and aged subjects. Methods Eight healthy middle and elderly subjects aged (57.3±5.0) years and 8 sex-matched healthy young subjects aged (28.3±3.4)years were enrolled iu this study. Conventional lung function tests were performed in all the subjects.Neural respiratory drive was assessed by electromyogram(EMG) recorded from a multipair esophageal electrode in quiescent condition and maximal forced inspiration. Results Maximal diaphragm EMG (EMGdi) at inspiration was similar between elderly and young subjects [(172.2 ± 54.66) μV vs.(175.0±55.7) μV,t -0.10,P=0.921] while vital capacity(VC) in the elderly subjects
[(3.2±0.5)L]
was
much
smaller
than
young
subjects[(4.0±0.8)L](t=-2.27,P＜0.05).The tidal volume and ventilatory capacity per minute in quiescent condition in middle and aged people were similar to the youth,however,EMGdi％max was higher in the elderly subjects (27.8± 12.9)％ than in the young subjects (16.4±7.2)％ (t-2.18,P＜0.05).Effective drive of respiration center was much less in the elderly subjects
than
in
young
subjects
[(62.7±23.2)
％
健康中老年人肺功能下降与呼吸中枢驱动变化的关系
