Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute l

Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury

model in rats

ZHU Yao-bin;ZHANG Yan-bo;LIU Dong-hai;LI Xiao-feng;LIU Ai-jun;FAN Xiang-ming;QIAO Chen-hui

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)004

【摘要】Background An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis,severe burns,and trauma.It is increasingly recognized that atrial natriuretic peptide (ANP) possesses a broad range of biological activities,including effects on endothelial function and inflammation.A recent study has revealed that ANP exerts anti-inflammatory effects.In this study we tested the effects of human ANP (hANP) on lung injury in a model of oleic acid (OA)-induced acute lung injury (ALl) in rats.Methods Rats were randomly assigned to three groups (n=6 in each group).Rats in the control group received a 0.9％ solution of NaCl (1 ml.kg1.h-1) by continuous intravenous infusion,after 30 minutes a 0.9％ solution of NaCl (1 ml/kg) was injected intravenously,and then the 0.9％ NaCl infusion was restarted.Rats in the ALl group received a 0.9％ NaCl solution (1 ml·kg-1·h-1) intravenous infusion,after 30 minutes OA was injected intravenously (0.1 ml/kg),and

then the 0.9％ NaCl infusion was restarted.Rats in the hANP-treated ALI group received a hANP (0.1μg·kg-1·min-1) infusion,after 30 minutes OA was injected intravenously (0.1 ml/kg),and then the hANP infusion was restarted.The anti-inflammation effects of hANP were evaluated by histological examination and determination of serum cytokine levels.Results Serum intedeukin (IL)-1β,IL-6,IL-10 and tumor necrosis factor (TNF) α were increased in the ALI group at six hours.The levels of all factors were significantly lower in the hANP treated rats (P ＜0.005).Similarly,levels of IL-1β,IL-6,IL-10 and TNF-α were higher in the lung tissue in the ALI group at six hours.hANP treatment significantly reduced the levels of these factors in the lungs (P ＜0.005).Histological examination

revealed

marked

reduction

in

interstitial

congestion,edema,and inflammation.Conclusion hANP can attenuate inflammation in an OA-induced lung injury in rat model. 【总页数】4页(747-750) 【关键词】

【作者】ZHU Yao-bin;ZHANG Yan-bo;LIU Dong-hai;LI Xiao-feng;LIU Ai-jun;FAN Xiang-ming;QIAO Chen-hui

【作者单位】Department of Pediatric Heart Center, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China;Department of Pediatric Heart Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease,

Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China;Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China;Department of Pediatric Heart Center, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China;Department of Pediatric Heart Center, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China;Department of Pediatric Heart Center, Beijing Anzhen Hospital,Capital Medical University, Beijing 100029, China;Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China 【正文语种】中文 【中图分类】 【文献来源】

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