酸枣仁提取物对尼古丁行为敏感化大鼠模型的疗效及作用
Jiao Yu;Wang Yefu;Wu Tong;Wang Xiaolong;Cui Guangcheng;Zhao Rongjie
【期刊名称】《神经疾病与精神卫生》 【年(卷),期】2019(019)003
【摘要】Objectives? To observe the therapeutic effect of Jujube seeds extract on the sensitisation of rat nicotine behaviour, and to explore its neurochemical mechanism. Methods? Thirty-six adult Sprague-Dawley (SD) rats were divided into normal saline group (group A), single nicotine group (group B), nicotine behavioural sensitisation model group (group C), and jujube seed low-dose treatment group (group D), high dose treatment group (group E) and high dose of jujube group (group F). Groups C, D and E were injected subcutaneously with nicotine [0.4 mg/(kg·d)] for 7 days. Groups A, B and F were injected with the same volume of normal saline for 7 days, and then discontinued for 3 days. During the withdrawal period, the D, E and F groups were administered with the jujube extract once a day respectively (low dose group: 60 mg/kg, high dose group: 180 mg/kg), and groups A, B and C were administered with equal volume of drinking water. On the third day, 1 hour after gastrointestinal administration, except for the A and F groups, the other groups of rats were given an activated dose of nicotine (0.4 mg/kg). Immediately after using the rat spontaneous activity detection system to detect the spontaneous activity of rats
酸枣仁提取物对尼古丁行为敏感化大鼠模型的疗效及作用
