疏血通联合参麦注射液对老年急性心梗患者再灌注后血清
hs-CRP、SOD及MDA水平的影响
张朝霞
【期刊名称】《中国生化药物杂志》 【年(卷),期】2017(037)008
【摘要】目的 探究疏血通联合参麦注射液对老年急性心梗PCI术后再灌注患者的血清CPR、SOD及MDA水平的影响,并分析主要不良心血管事件.方法 分层抽取邢台市第一医院心血管内科于2015年6月~2016年6月间收治的PCI患者88例,随机分为观察组及对照组,每组各44例.对照组在PCI术前给予常规药物治疗,在此基础上观察组在PCI术前加用疏血通联合参麦静脉注射治疗,2组患者的治疗均持续至PCI术后1周.对比2组PCI前及PCI后1 d、7 d的血清丙二醛(MDA)、超氧化物歧化酶(SOD)及超敏C反应蛋白(hs-CRP)水平,对比2组凝血因子水平、动态心电图、左心射血分数(LVEF)及心肌梗死面积的变化;同时比较PCI后2组PCI术后再灌注心律失常及主要不良心血管事件的发生情况.结果 PCI术后观察组血清MDA及hs-CRP水平均显著低于对照组(P<0.05),SOD水平显著高于对照组(P<0.05);PCI术后观察组凝血因子水平均显著高于对照组(P<0.05);PCI术后观察组LVEF显著高于对照组(P<0.01),心肌梗死面积、缺血发作次数、ST段下降幅度及ST段下降时间均显著低于对照组(P<0.01);术后6个月观察组MACE发生率显著低于对照组(P<0.05).结论 常规治疗联合疏血通联合参麦注射液可有效预防老年AMI患者PCI术后缺血再灌注损伤,有效改善心功能,并降低PCI术后主要不良心血管事件,体现了中西医结合的优势,值得临床推广使用.%Objective Study the effect of Shuxuetong combined with
Shenmai injection on serum CPR, SOD and MDA levels in elderly patients with acute myocardial infarction after PCI, and to analyze the main adverse cardiovascular events. Methods Chose 88 patients with PCI from June 2015 to June 2016 in our hospital, they were randomly divided into observation group and control group, 44 cases in each group. The control group was given conventional drug therapy before PCI. On the basis of this, the observation group was treated with Shuxuetong combined with Shenmai intravenous injection before PCI. The treatment of the two groups continued to one week after PCI. Compared the levels of serum malondialdehyde (MDA), superoxide dismutase (SOD) and hypersensitive C-reactive protein (hs-CRP) between the two groups before and after PCI, and compared the levels of coagulation factor, dynamic electrocardiogram, Left ventricular ejection fraction (LVEF) and myocardial infarct size, and compared the incidence of arrhythmia and major adverse cardiovascular events after PCI. Results The levels of serum MDA and hs-CRP in the observation group were significantly lower than those in the control group (P<0.05), the level of SOD was significantly higher than the control group (P<0.05); The level of coagulation factor in the observation group was significantly higher than that in the control group (P<0.05). The myocardial infarct size, the number of ischemic attacks, the decrease of ST segment and the descending time of ST segment were significantly
lower than those of the control group (P<0.01). The incidence of MACE was significantly lower in the observation group than in the control group (P<0.05). Conclusion Conventional treatment combined with Shuxuetong combined with Shenmai injection can effectively prevent ischemia-reperfusion injury in elderly patients with AMI, improve cardiac function and reduce the main adverse cardiovascular events after PCI, which reflects the combination of traditional Chinese and western medicine Advantages, worthy of clinical use. 【总页数】5页(38-41,44)
【关键词】疏血通;参麦;急性心肌梗死;缺血再灌注;hs-CRP;SOD;MDA 【作者】张朝霞
【作者单位】邢台市第一医院心血管内科,河北 邢台 054001 【正文语种】中文 【中图分类】R542.2 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-biochemical-pharmaceuticals_thesis/0201242949711.html 【相关文献】
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疏血通联合参麦注射液对老年急性心梗患者再灌注后血清hs-CRP、SOD及
