稳心颗粒对缺血大鼠心室肌电生理特性的影响
党松;张丹;胡娟;王晞
【期刊名称】《中国医药导报》 【年(卷),期】2012(009)011
【摘要】Objective To investigate the effect of the Chinese medical compound Wenxin Granule on the electrophysiologi-cal characteristics of ventricular myocytes in ischemia-reperfusion SD rats. Methods 40 SD rat were randomly divided into ischemia-reperfusion, 1,5, 10 g/L Wenxin Granule respectively treatment groups. 10 cases in each group. The left ventricle muscle tissue was separated immediately after rats were dislocated, and the wedge were perfused. Standard glass micro-electrode technique was used to record the transmembrane action potential and effective refractory period at the different cycle length stimulation. Results CDCompared with control group, the APA, APD, Vmax were decreased and ERP were reduced significantly in ischemia-reperfusion group (P < 0.05); while the APA, APD, Vmax were significantly increased in Wenxin Granule treatment groups (P < 0.05), and the ERP prolonged significantly in 5, 10 g/L Wenxin Granule respectively treatment groups compared with ischemia control group. ?The characteristic of frequency dependence in cardiac muscular tissue were weaken after perfused with ischemia solution. Wenxin Granule could recover the characteristics with the increase of dosing
稳心颗粒对缺血大鼠心室肌电生理特性的影响
