In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of India

In vitro antiplasmodial activity of methanolic extracts from seaweeds of South West Coast of

India

S Ravikumar;G Ramanathan;M Gnanadesigan;A Ramu;V Vijayakumar

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2011(000)011

【摘要】Objective:To identify thein vitro antiplasmodial activity of seaweed plants againstPlasmodium falciparum strains.Methods:A total of eight seaweeds were collected from Kanyakumari district, Tamilnadu, India. Thein vitro antiplasmodial activity was performed in 96 well plates againstPlasmodium falciparum, and preliminary phytochemcial analysis were

performed

for

the

extracts.Results:Of

the

selected

plantsEnteromorpha intestinalis(2.61%)showed maximum percentage of extraction. The minimum concentration of inhibitory(IC50)value was observed with Chaetomorpha antennina [(26.37±4.14)μg/mL] further, the positive controls such as chloroquine and artemether showed antiplasmodial activities(IC50) with(19.10±5.93) and(6.03±0.21)μg/mL concentrations, respectively. The preliminary phytochemical analysis of the seaweed extracts showed a variety of phytochemical constituents such as carboxylic acids, phenols, protein, resins, steroids and sugars.Conclusions: The antiplasmodial activity of the seaweed extract might due to the presence of sugars and phenolic compounds. From