他克莫司软膏治疗儿童特应性皮炎疗效和依从性评价
周动机;胡毅强;余健锋
【期刊名称】《实用皮肤病学杂志》 【年(卷),期】2013(000)004
【摘要】Objective To evaluate the efficacy, safety and compliance of tacrolimus ointment 0.03% for the children with mild to moderate atopic dermatitis. Methods In this 3-week, randomized, double-blind, placebo-controlled, parallel-group trial, sixty cases of children with atopic dermatitis were randomized 1:1 to receive treatment with topical 0.03%tacrolimus ointment or vaseline cream combined with fusidic acid ointment. Follow-up observations of the patients were carried out weekly, efifcacy was evaluated by the SCORAD index. Results Itching and symptom score in the experimental group declined more signiifcantly than that in the control group (P<0.05). The time to symptoms alleviation and clinical cure time for the experimental group were signiifcantly shorter than the control group (P<0.05). The effective rate of the experimental group and the control group were 93.3%and 69.5%, and the compliance rate of the experimental group and the control group were 100%and 76.7%respectively, there were signiifcant differences between the two groups (P<0.05). Conclusion Tacrolimus ointment 0.03%was effective in the treatment of children with mild to moderate atopic dermatitis, which with better safety and good
compliance.%目的评价0.03%他克莫司软膏治疗儿童轻、中度特应性皮炎（AD）的疗效和安全性及依从性。方法采用随机双盲平行对照方法将入选的60例AD患儿分为对照组和试验组，每组各30例。试验组患儿外用0.03%他克莫司软膏，对照组患儿外用凡士林乳膏、夫西地酸软膏，两组均连续治疗3周，采用AD评分评价疗效。结果试验组患儿瘙痒、症状积分下降明显大于对照组（P＜0.05）；症状控制时间和临床治愈用药时间明显短于对照组（P＜0.05）。试验组和对照组治疗的有效率分别为93.3%和69.5%，两组疗效比较差异有统计学意义（P＜0.05）；试验组和对照组依从率分别为100%和76.7%，两组比较差异具有统计学意义（P＜0.05）。结论0.03%他克莫司软膏治疗儿童轻、中度AD安全而有效，患儿依从性良好。 【总页数】3页(207-209)
【关键词】皮炎,特应性;他克莫司;儿童 【作者】周动机;胡毅强;余健锋
【作者单位】广东省开平市中心医院皮肤科,529300;广东省开平市中心医院皮肤科,529300;广东省开平市中心医院皮肤科,529300 【正文语种】中文 【中图分类】R758.231 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_journal-practical-dermatology_thesis/0201238127905.html 【相关文献】
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他克莫司软膏治疗儿童特应性皮炎疗效和依从性评价
