巴戟天醇提物对D-半乳糖致衰老大鼠免疫功能的影响
王雪侠;张向前
【期刊名称】《中国医药导报》 【年(卷),期】2013(010)004
【摘要】目的 探讨巴戟天醇提物对D-半乳糖致衰老大鼠免疫功能的影响.方法 50只健康雄性Wistar大鼠随机均分为空白对照组、模型对照组、维生素E组、巴戟天高剂量组和巴戟天低剂量组,每组各10只.利用D-半乳糖制作衰老大鼠模型,并用维生素E及两种不同剂量的巴戟天醇提物进行灌胃.给药结束后,检测大鼠的胸腺指数、脾脏指数、T淋巴细胞转化指数、B淋巴细胞转化指数、白介素-2(IL-2)水平以及CD28阳性淋巴细胞数.结果 与模型对照组比较,维生素E组、巴戟天高剂量组和巴戟天低剂量组胸腺指数、脾脏指数、T淋巴细胞转化指数、B淋巴细胞转化指数、IL-2水平以及CD28阳性淋巴细胞数明显升高,差异均有统计学意义(均P < 0.05).结论 巴戟天醇提物能够增强D-半乳糖致衰老大鼠的免疫功能,可能具有延缓衰老的作用.%Objective To investigate the effects of radix Morindae officinalis ethanolic extracts on immune function In rals induced by D---galactose. Methods 50 healthy male Wistar rats were randomly divided Into 5 groups: the blank control group, the model group, the vitamin F. group, the radix Morindae officinalis high dose group and the radix Morindae officinalis low dose group with 10 rats in each group. The aged rats were induced by D galactose, and rats in all the administration groups were respectively given Vitamin E, high dose or low dose of radix Morindae officinalis. The thymus gland Index,
spleen Index, T lymphocyte stimulation Index, B lymphocyte stimulation Index, level of inter-leukin-2 (IL-2), cell amount with positive CD28 were detected in all the 5 groups. Results Compared with the model group, the thymus gland index, spleen index, 1 lymphocyte stimulation Index, B lymphocyte stimulation index, level of IL--2, cell amount with positive CD28 were all higher in the vitamin E group, the radix Morindae officinalis high dose group and the radix Morindae officinalis low dose group, the differences were all statistically significant (all P＜0.05). Conclusion Radix Morindae officinalis ethanolic extracts can enhance the immune function of rats induced by D galactose, and It. can delay the aged.
【总页数】3页(17-19)
【关键词】巴戟天醇提物;D-半乳糖;免疫功能;刺激指数;白介素-2;CD28 【作者】王雪侠;张向前
【作者单位】郑州大学基础医学院,河南郑州,450000;郑州市妇幼保健院检验科,河南郑州,450000;河南电力医院检验科,河南郑州,450000 【正文语种】中文 【中图分类】R393 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_china-medical-herald_thesis/0201252955964.html 【相关文献】
1.异常黑胆质成熟剂对D-半乳糖致衰老模型大鼠免疫功能的影响 [J], 阿不都热衣木·肉孜; 艾克柏尔·阿布都热合曼; 古孜力努尔·依马木; 哈木拉提·吾甫尔; 阿不都热依木·玉苏甫
2.艾灸益气活血法对D-半乳糖致衰老大鼠免疫功能的影响 [J], 李霞; 唐中生 3.艾灸益气活血法对D-半乳糖致衰老大鼠免疫功能的影响 [J], 李霞[1]; 唐中生[2]
4.甘草水提物干预D-半乳糖致衰老大鼠的肝脏代谢组学研究 [J], 赵凡凡; 李肖; 高丽; 秦雪梅; 杜冠华; 周玉枝
5.细脚拟青霉提取物对D-半乳糖致衰小鼠免疫功能的影响 [J], 桂琳; 葛飞; 董群; 刘辉; 陈京; 周小楠
以上内容为文献基本信息，获取文献全文请下载
巴戟天醇提物对D-半乳糖致衰老大鼠免疫功能的影响
