血浆同型半胱氨酸、一氧化氮对动脉粥样硬化作用的探讨
陈琦玲;王鸿懿;孙宁玲
【期刊名称】《中国医学前沿杂志（电子版）》 【年(卷),期】2013(000)009
【摘要】目的探讨高血压及伴冠心病的动脉粥样硬化患者血浆同型半胱氨酸（Hcy）、一氧化氮（NO）变化的特性。方法对高血压或伴冠心病患者通过颈动脉超声及冠状动脉造影明确存在动脉粥样硬化的患者211例，冠心病/高血压病患者99例，高血压122例，进行Hcy、NO及超敏C反应蛋白（hs-CRP）测定。结果冠心病患者血浆Hcy浓度为（18.57±7.47）μmol/L，明显高于单纯高血压组（14.53±10.58）μmol/L（P＜0.01），hs-CRP水平（3.73±3.89）mg/L，明显高于高血压组（2.38±2.86）mg/L，P＜0.05。冠心病患者血清NO浓度为（51.15±18.78）μmol/L，显著低于高血压组（70.39±41.55）μmol/L，P＜0.001。结论 Hcy、NO及hs-CRP的异常与动脉粥样硬化的发展有关，冠心病冠状动脉粥样硬化伴颈动脉粥样硬化多部位血管病变患者的Hcy与NO水平反比的程度以及hs-CRP明显高于高血压伴颈动脉病变的单部位的患者，提示Hcy水平及炎症参与了血管损伤的过程。%Objective To explore the serum level of homocysteine (Hcy), nitric oxide (NO) in patients with or without coronary heart diseases and the relationship between vasoactive substances and carotid atherosclerosis. Methods Serum Hcy, NO and hs CRP levels were measured in 211 hospitalized patients, among them 99 with coronary heart disease (diagnosed by coronary angiography) and 122 with essential hypertension. Results Serum Hcy
concentration was (18.57±7.47) μmol/L in CHD patients, which was higher
signiifcantly
than
that
in
hypertensive
patients
(14.53±10.58)μmol/L (P < 0.01). Serum NO concentration in CHD patients was lower signiifcantly than that in simple hypertension patients (P<0.001), the mean level was (51.15±18.78) μmol/L and (70.39±41.55) μmol/L respectively. 94.1% patients complicated with carotid artery lesions in CHD group, which was higher signiifcantly than that
in
hypertension
group,
P
<
0.001.
Conclusion
High
homocysteinemia is closely related to the occurrence of coronary heart disease. Hcy levels was inversely proportional to NO levels, which relfecting the obvious relevance of Hcy levels to the severity of vascular injury. Carotid artery lesions and coronary artery disease was positively correlated. The simple, non-invasive and reproducible method of carotid artery ultrasound is expected to become the window of observing the coronary artery diseases. 【总页数】4页(40-43)
【关键词】冠心病;高血压;动脉粥样硬化,同型半胱氨酸;一氧化氮 【作者】陈琦玲;王鸿懿;孙宁玲
【作者单位】北京大学人民医院 心脏中心，北京 100044;北京大学人民医院 心脏中心，北京 100044;北京大学人民医院 心脏中心，北京 100044 【正文语种】中文 【中图分类】
【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-frontiers-medical-science-electronic-version_thesis/0201254192118.html 【相关文献】
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血浆同型半胱氨酸、一氧化氮对动脉粥样硬化作用的探讨
