FRAT1和β-catenin在人类脑胶质瘤中的表达及其意义
郭庚;章翔;蒯东;薛乃照;刘跃亭;郝解贺
【期刊名称】《肿瘤研究与临床》 【年(卷),期】2013(025)005
【摘要】Objective To investigate the expression of FRAT1 and β-catenin in human brain glioma,analyze the correlation between the expression and clinical pathological grades and the correlation of the two genes.Methods
FRAT1
and
β-catenin
were
detected
by
immunohistochemistry in 84 human brain glioma tissues and 6 human normal brain tissues.Results 66.7 ％ (56/84) and 77.4 ％ (65/84) of human brain glioma tissues expressed FRAT1 and β-catenin protein,whereas no FRAT1 and β-catenin protein expression was detected in human normal brain tissues.The expression levels of FRAT1 and ββ-catenin increased markedly with the ascending of pathologic grade of tumor specimens (r =0.55,P ＜ 0.01,r =0.70,P ＜ 0.01),there was a positive correlation between FRAT1 and β-catenin (r =0.77,P ＜ 0.01).Conclusion FRAT1 and β-catenin over-expression maybe closely related with occurrence and development of human brain gliomas.The results provide important supplements for the research of Wnt/β-catenin pathway.Meanwhile,FRAT1 may act as a valuable biomarker for molecular diagnosis of glioma and a potential target for gene therapy of glioma.%目的 探讨FRAT1、β-catenin蛋白在人类脑胶质瘤中的表达情况
FRAT1和β-catenin在人类脑胶质瘤中的表达及其意义
