Poly(ethylene glycol)-supported Liquid-phase Parallel Synthesis of Di(aryloxyacetyl)thiose

Poly(ethylene glycol)-supported Liquid-phase

Parallel Synthesis of

Di(aryloxyacetyl)thiosemicarbazides

Xi Cun WANG;Jun Ke WANG;Zheng LI

【期刊名称】《中国化学快报（英文版）》 【年(卷),期】2004(015)006

【摘要】An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi- carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4'-

methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity. 【总页数】2页(635-438) 【

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Liquid-phase

synthesis;PEG;di(aryloxyacetyl)thiosemicarbazide 【作者】Xi Cun WANG;Jun Ke WANG;Zheng LI

【作者单位】College of Chemistry and Chemical Engineering, Northwest