纹状体参与联想学习记忆的功能磁共振成像和临床研究
郑金龙;赵连东;曹向阳;张增强;舒斯云
【期刊名称】《中华行为医学与脑科学杂志》 【年(卷),期】2009(018)010
【摘要】Objective To examine whether the striatum are involved in associative learning and memory cognitive function of human brain by functional magnetic resonance imaging (fMRI) technique and clinical observation.Methods 14 right-handed normal volunteers participated in a test of paired-word associative learning and memory ,while the fMRI data were recorded.Control tasks were performed for the block-design.SPM 99 was used to analyze the data and to obtain the activated brain regions.14 patients with striatum damages and 14 matched normal volunteers participated in a test of paired-word associative learning and memory.Results When the threshold was set as P＜0.005 ,using a one-sample t -test ,the left occipital lobe (t=13.87)were activated remarkably during the encoding process of the paired-word associative learning and memory task.However,during the retrieval process,the prominently activated brain regions were the left parietal lobe (t=8.73).The striatum (t=7.02/7.47) were also obviously activated during these two stages.The scores of the paired-word associative learning and memory test on the patients with striatum damages and the
healthy volunteers were respectively 11.53±1.39 and
纹状体参与联想学习记忆的功能磁共振成像和临床研究
