In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and ant

In vivo screening of essential oils of Skimmia laureola leaves for antinociceptive and antipyretic

activity

Naveed

Muhammad;Barkatullah;Muhammad

Ibrar;Haroon

Khan;Muhammad

Saeed;Amir Zada Khan;Waqar Ahmad Kaleem

【期刊名称】《亚太热带生物医学杂志（英文版）》 【年(卷),期】2013(000)003

【摘要】Objective:To study the screening of essential oils of Skimmia laureola leaves (SLO) for acute toxicity, antinociceptive, antipyretic and anticonvulsant activities in various animal models. Methods: SLO were extracted using modified Clevenger type apparatus. Acute toxicity test was used in mice to observe its safety level. Antinociceptive activity of SLO was evaluated in acetic acid induced writhing and hot plate tests. Yeast induced hyperthermic mice and pentylenetetrazole induced convulsive mice were used for the assessment of its antipyretic and anticonvulsant profile respectively. Results: Substantial safety was observed for SLO in acute toxicity test. SLO showed a high significant activity in acetic acid induced writhing test in a dose dependent manner with maximum pain attenuation of 68.48%at 200 mg/kg i.p. However, it did not produce any relief in thermal induced pain at test doses. When challenged against pyrexia evoked by yeast, SLO manifested marked amelioration in hyperthermic mice, dose dependently. Maximum anti-