Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumat

Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid

arthritis

Yuwei He;Ruixiang Li;Jianming Liang;Ying Zhu;Shuya Zhang;Zicong Zheng;Jing Qin;Zhiqing Pang;Jianxin Wang

【期刊名称】《纳米研究（英文版）》 【年(卷),期】2024(011)011

【摘要】The effective drug treatment of rheumatoid arthritis (RA) is hindered by poor delivery efficiency to the diseased site and the serious side effects caused by wide-spread drug distribution.Traditional drug-targeting

strategies,such

as

ligand

modification,are

complex,laborious,and inefficient.Inspired by the intrinsic relationship between platelets and RA,platelet-mimetic nanoparticles (PNPs) were developed for targeted drug delivery in RA.Through platelet receptor-mediated adhesion,an intact platelet membrane was coated onto poly (lactic-co-glycolic acid) nanopartides,endowing the resulting PNPs with various functional receptors.By coating with platelet membranes,the nanoparticles

were

stabilized

and

had

a

better

circulation

profile,providing a benefit for passive targeting.In vitro binding of PNPs to inflamed endothelium,and in vivo accumulation in joints of a collagen-induced arthritis (CIA) mouse model of RA were significantly improved via P-selectin and GVPI recognition,indicating that the PNPs