香丹注射液配伍组对异丙肾上腺素诱导大鼠心肌缺血损伤
的保护作用
杨超燕;沈志滨;陈东波;陈月凤;唐春萍
【期刊名称】《广东药学院学报》 【年(卷),期】2012(028)001
【摘要】Objective To investigate the cardioprotective effect of compound extracts (ADE) of xiangdan injection in rats with isoproterenol( ISO) induced myocardial injury. Methods Myocardial ischemia of rats was induced by subcutaneous injection of isoprenaline (2 mg · Kg-1 ) and intrapertitoneal injection of isoprenaline once a day for consecutive 3 days. The descent of J point at different time after injecting isoprenaline were examined, and the serum lactate de-hydrogenase ( LDH), creatine kinase (CK), superoxiade dismutase ( SOD) ,malondial dehyde( MDA) in the myocardial homogenate were measured; the hearts were examined with microscope. Results ADE group significantly improved the descent of J point after injecting isoprenaline,reduced the activities of LDH and showed less histological change than that in the model control group. Conclusion Compound extracts ( ADE) of xiangdan injection and xiangdan injection have the same protective effect against isoproterenol induced myocardial injury in rats.%目的 观察香丹注射液配伍组(ADE)对异丙肾上腺素(ISO)诱导大鼠心肌缺血损伤的保护作用.方法 采用大鼠皮下多点注射ISO(2 mg·kg-1),观察ADE
香丹注射液配伍组对异丙肾上腺素诱导大鼠心肌缺血损伤的保护作用
