金黄色葡萄球菌临床分离株对夫西地酸的耐药性分析
陈舒影;林纯婵;卢超慧;刘云玲;张雪青;王良兴;余方友
【期刊名称】《中国临床药理学杂志》 【年(卷),期】2015(031)019
【摘要】Objective To investigate the prevalence of fusidic acid ( FA) resistance among Staphylococcus aureus clinical isolates.Methods Five hundred fifty -five Staphylococcus aureus isolates were isolated from the various specimens of patients at the first affiliated hospital of Wenzhou medical university from January , 2009 to September , 2013. The susceptibility of Staphylococcus aureus isolates to FA and clinically often used antimicrobials was determined by disc diffusion method .The minimal inhibitory concentrations ( MICs ) of FA and vancomycin for FA-resistant isolates was determined by agar dilution method . Results Among 555 Staphylococcus aureus isolates, 293 were methici-llin-resistant Staphylococcus aureus ( MRSA) and 262 were methicillin-susceptible Staphylococcus aureus ( MSSA ) .Seventy -seven of 555 ( 13.87%) isolates including 60 MRSA and 17 MSSA isolates were resistant to FA.The rates of FA resistance among MRSA and MSSA iso-lates were 22.90% ( 60/262 ) and 5.80% ( 17/293 ) . The rates of FA resistance among Staphylococcus aureus isolates from 2009 to 2013 were 7.81% ( 5/64 ) , 9.80% ( 5/51 ) , 22.92%(11/48), 5.21%(11/211) and 24.86%(45/181), respectively.The MICs of FA for 77 FA -resistant isolates
金黄色葡萄球菌临床分离株对夫西地酸的耐药性分析
