Novel chromosomal alterations detected in primary nasopharyngeal carcinoma by comparative

Novel chromosomal alterations detected in primary nasopharyngeal carcinoma by comparative

genomic hybridization

鄢践方嬿;梁启万;方嬿;黄贻学;曾益新

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2001(114)004

【摘要】Objective To gain a better understanding of genetic changes inCantonese nasopharyngeal carcinoma (NPC). Methods Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas. Results A novel copy number gain an chromosome 4q and loss of chromosome 1p were found at a high frequency

(>50%).

Conclusions

Current

analysis

revealed

a

comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and 1q as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.%目的探讨广东籍病人原发性鼻咽癌(NPC)新的DNA拷贝数变化。方法用比较基因组杂交技术(CGH)检测17例原发性鼻咽癌遗传物质的增多和丢失情况。 结果在半数以上病人中发现4q增多和1p丢失。此外，还发现其它一些较高频发生的新的基因组DNA 变化。 结论广东原发性NPC的遗传学改变以4q、12q、1q增多和1p、3p、11q、14q、15q、13q、Xq、9q、10p、10q与16q 丢失为特点。这些发现可为下一步NPC相