高级别脑胶质瘤术后同步放化疗的疗效观察
常世川;范仕兵;李刚
【期刊名称】《现代肿瘤医学》 【年(卷),期】2013(021)001
【摘要】Objective: To explore the clinical effects of brain malignant glioma treated with postoperative radiotherapy and chemotherapy. Methods: Selected 74 cases of glioma, which randomly divided into radiation group (A) and radiotherapy plus chemotherapy group (B) ,37 patients in each group. Group A treated with postoperative three - dimensional conformal radiotherapy, 3 -4Gy each time,3 times/week,a total of 15 to 20 times,56 - 60Gy total dose. Giving group B the same radiation with group A,in addition,group B received temozolomide (TMZ) concurrent chemotherapy. Results:There were 12 cases in group B completely eased. 15 cases were partial remission,the effective rate was 72. 97% ;but only 5 cases were complete remission in group A, 7 cases were partial remission , efficiency was 32. 43% . Comparison of two groups,the difference was statistically significant (P <0. 01). KPS score in 2 groups,the difference was also statistically significant (P < 0. 01). Conclusion: Concurrent chemoradiotherapy is more effective than radiotherapy alone in postoperative malignant glioma.%目的:探讨脑胶质瘤术后行同步放化疗的疗效.方法:选取74例高级别脑胶质瘤患者,随机分为放疗组(A组)和放疗+化疗组(B组),每组各37例.A组术后行三维适形放疗,每次3-