多囊卵巢综合征患者空腹血清Ghrelin水平变化及相关因
素分析
杜娟;王长江;胡红琳;代芳
【期刊名称】《安徽医科大学学报》 【年(卷),期】2013(048)002
【摘要】Objective To evaluate the variation of fasting serum ghrelin and relative
factors
in
rnrnpatients
with
poly-cystic
ovarian
syndrome( PCOS ). Methods 48 patients rnrnand 32 controls were selected and each group was divided into rnrnoverweight/obese and non-obese subgroups according to body mass index ( rnrnBMI )≤25 kg/m2 or <25 kg/m2. The concentration of fasting serum ghrelin rnrnwas assayed by ELISA. Meanwhile, fasting levels of luteinizing hormone ( rnrnLH ), follicle stimulating hormone ( FSH ), testosterone( T ), plasma rnrnglucose( FPG )and insulin( FINS ) were also measured.
Anthropometric
rnrnmeasurement,
BMI,
waist-hip
ratio( WHR ) HOMA-IR and H0MA-β were also rnrncalculated . Results ① Fasting plasma ghrelin level was significantly rnrnlower in PCOS groups versus controls ( P < 0. 01 ) and overweight / obese rnrnsubgroup was lower than non-obese subgroup ( P < 0. 01 )in PCOS; ② rnrnFasting serum ghrelin level correlated negatively with BMI, WC, WHR, rnrnFINSln, H0MA-IRln, HOMA-βln (r = - 0. 774, - 0. 649, - 0. 553, - 0. 590, rnrn- 0. 575 , - 0. 431, P < 0. 01 ); ③ Multiple stepwise
regression analysis rnrnshowed that BMI was the independent influential factor of serum ghrelin rnrnlevel. Conclusion Lower ghrelin level may be a protective factor in P-COS rnrnwith obesity and insulin resistance.%目的 探讨多囊卵巢综合征(PCOS)患者空腹血清Ghrelin水平变化及相关性因素.方法 选取48例PCOS患者(PCOS组)和32名正常体检者(对照组),PCOS组按照体质指数(BMI)≥25 kg/m2或＜25 kg/m2,又各自分为超重/肥胖(PCOSObesity)亚组和体重正常(PCOSLean)亚组.采用酶联免疫吸附法测定各组空腹血清Ghrelin水平,同时检测黄体生成素、卵泡刺激素、睾酮(T)、空腹血糖(FPG)和胰岛素(FINS)水平;测量身高、体质量、腰围(WC)、臀围;并计算BMI、腰臀比(WHR)、稳态模型胰岛素抵抗指数(HOMA-IR)和胰岛β细胞分泌功能(HOMA-β).FINS、HOMA-IR、HOMA-β经对数转化为FINSln、HOMA-IRln和HOMA-βln后符合正态分布.结果① PCOS组空腹血清Ghrelin水平低于对照组,PCOSObesity亚组空腹Ghrelin水平低于PCOSLean 亚组(P＜0.01);② Pearson相关分析显示,PCOS组空腹血清Ghrelin水平与BMI、WC、WHR、FINSln、HOMA-IRln与HOMA-βln( r=-0.774、-0.649、-0.553、-0.590、-0.575、-0.431,P＜0.01)呈负相关;③ 多元逐步回归分析显示,BMI是影响Ghrelin水平的独立相关因素.结论 Ghrelin水平降低可能是控制PCOS患者肥胖和胰岛素抵抗进一步发展的保护性因素. 【总页数】4页(178-181)
【关键词】多囊卵巢综合征;胃促生长素;胰岛素抵抗 【作者】杜娟;王长江;胡红琳;代芳
【作者单位】安徽医科大学第一附属医院内分泌科,合肥,230022;安徽医科大学
第一附属医院内分泌科,合肥,230022;安徽医科大学第一附属医院内分泌科,合肥,230022;安徽医科大学第一附属医院内分泌科,合肥,230022 【正文语种】中文 【中图分类】R711.75 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_acta-universitatis-medicinalis-anhui_thesis/0201243348477.html 【相关文献】
1.初诊多囊卵巢综合征患者空腹血清Pentraxin3的水平变化及意义 [J], 张雨; 胡红琳; 王岩; 王长江
2.多囊卵巢综合征患者血清Apelin水平变化及相关因素分析 [J], 王芳; 蒋玲; 邓晓惠; 于红玲
3.多囊卵巢综合征患者血清adropin、Ghrelin水平及其相关因素分析 [J], 张颖; 雷洁; 张静
4.血清促生长激素释放激素受体配体(Ghrelin)水平与多囊卵巢综合征的相关性分析 [J], 文璞; 崔伟
5.多囊卵巢综合征患者血清Ghrelin水平与胰岛素抵抗关系的研究 [J], 谢秋娴; 杨纯; 郑曼嘉; 黄韩蔚; 陈婵玉
以上内容为文献基本信息，获取文献全文请下载
多囊卵巢综合征患者空腹血清Ghrelin水平变化及相关因素分析
