PEDF、END在UUO肾组织的表达及ADSCs对其的影响
吕春燕;杨天林;李进辉;吴程;王丽;陈昌金;赵梓亦
【期刊名称】《中国现代医学杂志》 【年(卷),期】2018(028)002
【摘要】Objective To observe the dynamic changes of pigment epithelium-derived factor (PEDF) and endostatin (END) expressions in renal tissues 3, 7 and 14 days after unilateral ureteral obstruction (UUO) in rats and the expression changes after the intervention of adipose-derived stem cells, so as to explore the possible mechanism of PEDF and END in UUO and the relationship between them and the effect of adipose-derived stem cells on the expressions of PEDF and END in the course of UUO. Methods Seventy healthy adult male SD rats were randomly divided into sham operation control group (10 rats), UUO group (30 rats) and intervention group (30 rats). The UUO model was produced by unilateral ureteral obstruction and the rats in the intervention group were injected with adipose-derived stem cells in 24 hours. On the 3rd, 7th and 14th day after ureteral obstruction, the progression of renal injury and fibrosis and the expressions of PEDF and END in rats were observed. Results The renal injury and fibrosis got more severe with the prolongation of the time of obstruction, the expressions of PEDF and END in the UUO group were higher than those of the control group at each time point. The expressions of END and
PEDF、END在UUO肾组织的表达及ADSCs对其的影响
