Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomac

Clinicopathological Characteristics and Prognosis

of Hepatoid Adenocarcinoma of the Stomach:Evaluation of a Pooled Case Series

Xiang-yu ZENG[1];Yu-ping YIN[1];Hua XIAO[2];Peng ZHANG[1];Jun HE[3];Wei-zhen LIU[1];Jin-bo GAO[1];Xiao-ming SHUAI[1];Guo-bin WANG[1];Xiu-li WU[3];Kai-xiong TAO[1];

【期刊名称】《当代医学科学(英文)》 【年(卷),期】2018(038)006

【摘要】Hepatoid adenocarcinoma of the stomach (HAS)is an extremely rare and unique gastric malignancy.The present study aimed to examine the relevance of the clinicopathological characteristics of HAS with patient prognosis.We retrospectively reviewed clinical data of 34 HAS patients treated at our institution between January 2010 and December 2016,as well as 294 cases reported prior to 2017 in research databases.Among these patients,45.6%(115/252)had lesions in the gastric antrum and 77.0%(235/305)were male.Elevated levels of serum alpha-fetoprotein

(AFP)were

detected

in

most node

patients(75/93,80.6%).Vascular metastasis

invasion(199/286,69.6%),lymph

preoperative

distant

(222/283,78.4%),and metastasis

(121/328,36.9%)were commonly observed.The 5-year disease-free survival (DFS)and disease-specific survival (DSS) were 20.7%and 29.2%,respectively.DFS and DSS of patients receiving neoadjuvant

therapy were significantly higher than those of patients receiving postoperative adjuvant therapy [DFS:P<0.001, hazard ratio (HR)=-1.831,95%confidence interval (CI):0.060-0.429;DSS:P<0.001,HR=-2.185, 95%CI:0.032-0.401].In

conclusion,HAS

exhibits

distinct

clinicopathological characteristics and a strikingly worse prognosis when compared with common gastric cancer.Complete surgery,early pTNM stage,and adjuvant therapy may predict a more favorable prognosis.Neoadjuvant therapy is strongly recommended for patients with lymph node metastasis or/and preoperative distant metastasis. 【总页数】8页(P.1054-1061)

【关键词】hepatoid adenocarcinoma;stomach;clinicopathological characteristics;adjuvant therapy;neoadjuvant therapy;prognosis

【作者】Xiang-yu ZENG[1];Yu-ping YIN[1];Hua XIAO[2];Peng ZHANG[1];Jun

HE[3];Wei-zhen

LIU[1];Jin-bo

GAO[1];Xiao-ming

SHUAI[1];Guo-bin WANG[1];Xiu-li WU[3];Kai-xiong TAO[1];

【作者单位】[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[2]Department

of

Gastroduodenal

and

Pancreatic

Surgery,Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University,Changsha

410013,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[3]Department

of

Pathology,Union

Hospital,Tongji

Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[3]Department

of

Pathology,Union

Hospital,Tongji

Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;[1]Department of Gastrointestinal Surgery,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China; 【正文语种】英文 【中图分类】R 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_current-medical-science_thesis/0201270128418.html