体部伽玛刀治疗中晚期胰腺癌156例临床疗效观察

体部伽玛刀治疗中晚期胰腺癌156例临床疗效观察

虞晓林;罗卫华;李昌林;蒙荣钦;张光宇;王阳;周国懿

【期刊名称】《现代肿瘤医学》 【年(卷),期】2011(019)007

【摘要】Objective: To investigate the clinical therapeutic effectiveness of body r - knife in patients with advanced pancreatic carcinoma. Methods: One hundred and fifty - six patients with advanced pancreatic carcinoma were treated with body r - knife therapy. The dosage distribution and other radiotherapeutic plans were established on the basis of carcinoma position. The isodose carve was 50％ -60％ and covered the target volume The single dose was 350 -450cGy. The radiation was performed once everyday for 10 - 14time. Results: Among 156 patients who received CT after 2 to 6months of the therapy, 20 cases achieved complete response and 114 cases achieved partial response, remained unchanged inl6 patients , and enlarged in 6 patients, the 6 - month, 12month, 24 - month overall survival rates were 88.5,40.4 and 11.5 . No perforation serious bleeding or continuous high fever was observed.Conclusion: Body r - knife can achieve a high local control rate and survival rate. Its clinical therapeutic effectiveness is satisfactory. Body r - knife is a safe and reliable treatment option for patients with locally advanced pancreatic carcinoma.%目的:观察体部伽玛刀治疗中晚期胰腺癌的临床疗效.方法:对156例中晚期胰腺癌,采用体部伽玛刀治疗.根据病灶

的形状,大小及患者的身体状况,确定治疗次数及分次剂量,取50%-60%的等剂量曲线覆盖靶区,单次剂量300-450CGY,治疗10-14次,每日一次,总剂量4000-4500CGY.结果:治疗结束后2-6月CT复查156例,肿瘤完全缓解20例(12.8%),部分缓解114例(73.1%),稳定16例(10.3%),进展6例(3.8%),治疗后随访生存6月138例(88.5% ),生存12月 63例(40.4%),24月以后生存18例(11.5%).体部伽玛刀治疗未见穿孔、大出血、持续高热等严重并发症.结论:体部伽玛刀治疗中晚期胰腺癌临床疗效较好,是一种安全、可靠的治疗方法,为临床医生提供了一种新的治疗手段.

【总页数】2页(1379-1380)

【关键词】体部伽玛刀;胰腺癌;临床疗效

【作者】虞晓林;罗卫华;李昌林;蒙荣钦;张光宇;王阳;周国懿

【作者单位】363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041;363医院肿瘤科,四川,成都,610041 【正文语种】中文 【中图分类】R735.9 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_journal-modern-oncology_thesis/0201236454751.html 【相关文献】

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