2型糖尿病合并非酒精性脂肪性肝病与胰岛素抵抗及血脂代谢紊乱的关系

2型糖尿病合并非酒精性脂肪性肝病与胰岛素抵抗及血脂代

谢紊乱的关系

赵玲;杜娟;徐勉;牛学琴;柯亭羽;潘毅

【期刊名称】《中华内分泌代谢杂志》 【年(卷),期】2012(028)001

【摘要】Objective To investigate the association of nonalcoholic fatty liver disease (NAFLD) with insulin resistance and dyslipidemia in patients with type 2 diabetes mellitus,and to analyze the risk factors.Methods A total of 200 patients with type 2 diabetes mellitus including

99

with

NAFLD

and

101

without

NAFLD

were

recruited.Height,weight,waist circumference,hip circumference,liver

enzymes,blood lipids,fasting and postprandial blood glucose,insulin,C-peptide,and HbA1C levels were detected.Body mass index ( BMI),waist-hip ratio( WHR),and improved insulin and C-peptide index(HOMA-C-peptide) were calculated and compared between two groups.Results Compared with non-NAFLD group,weight,BMI,waist circumference,hip circumference,alanine

aminotransferase

(

ALT),aspartate

aminotransferase,triglyceride ( TG ),total cholesterol ( TC ),low density lipoprotein-cholesterol(LDL-C) were significantly higher in NAFLD group( all P＜0.01 ),while age,duration,and high density lipoprotein-cholesterol were lower( all P＜0.05 ).The incidence of combined hyperlipidemia,especially hypertriglyceridemia,was significantly higher