Micronuclei rate and hypoxanthine phosphoribosyl transferase mutation in radon-exposed rats

Micronuclei rate and hypoxanthine phosphoribosyl

transferase mutation in radon-exposed rats

Fengmei Cui;Saijun Fan;Mingjiang Hu;Jihua Nie;Hongmei Li;Jian Tong

【期刊名称】《自然科学进展（英文版）》 【年(卷),期】2008(018)010

【摘要】The genetic changes in rats with radon exposure were studied by the micronucleus technology and detection of hypoxanthine phosphoribosyl transferase (hprt) mutations.The rate of the micronuclei in peripheral blood lymphocytes and tracheal-bronchial epithelial cells in the radon-inhaled rats was higher than that of the controls (P ＜ 0.05).A similar result was obtained from the hprt assay,which showed a higher mutation frequency in radon-exposed rats.Our results suggested that micronuclei rate and hprt deficiency could be used as biomarkers for the genetic changes with radon exposure. 【总页数】4页(1305-1308)

【关键词】Radon;Tracheal-bronchial epithelial cell;Peripheral blood lymphocyte;Mieronuclei;Hypoxanthine phosphoribosyl transferase 【作者】Fengmei Cui;Saijun Fan;Mingjiang Hu;Jihua Nie;Hongmei Li;Jian Tong

【作者单位】Department of Radiotoxicology,School of Radiation Medicine and Public Health,Suzhou University,Suzhou Industry Park,Ren'ai

Road

199,Suzhou

215123,China;Department

of