Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ure

Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral

stones

ZHANG Meng-yuan;DING Sen-tai;L(U) Jia-ju;LUE Yan-he;ZHANG Hui;XIA Qing-hua

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2009(122)007

【摘要】Background Tamsulosin,an alpha-1 receptor antagonist,has been demonstrated effective in promoting distal ureteral stone passage and in reducing pain associated with stone expulsion.This study aimed to evaluate the effect of tamsulosin in comparison with nifedipine and extracerporeal shock wave lithotripsy (ESWL) on the expulsion rate of distal ureteral stones at different sizes.Methods We assigned 314 patients to three categories:Ⅰ,the stone with maximal diameter of 4.0-5.9 mm;Ⅱ,6.0-7.9mm,and Ⅲ,8.0-9.9 mm.Patients in each category were randomly subdivided into three treatment subgroups:group A (nifedipine group),group B (tamsulosin group),and group C (ESWL group).Stone-free rate and the dose of analgesics were recorded weekly during the 4-week follow-up period.Results Three hundred and three patients completed the study.The results showed that nifedipine and tamsulosin treatments promoted a small (4-8 mm,categories Ⅰ and Ⅱ) stone

expulsive

rate

that

was

comparable

with

ESWL

treatment.Nonetheless,when the stone diameter was 8.0-9.9 mm,ESWL