Efficacy and Safety of Different Bisphosphonates for Bone Loss Prevention in Kidney Transp

Efficacy and Safety of Different Bisphosphonates for Bone Loss Prevention in Kidney Transplant

Recipients: A Network Meta-Analysis of

Randomized Controlled Trials

Yah Yang;Shi Qiu;Xi Tang;Xin-Rui Li;Ling-Hui Deng;Qiang Wei;Ping Fu

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2018(131)007

【摘要】Background:Mineral and bone disorder is one of the severe complications in kidney transplant recipients (KTRs).Previous studies showed that bisphosphonates had favorable effects on bone mineral density (BMD).We sought to compare different bisphosphonate regimens

and

rank

their

strategies.Methods:We

searched

PubMed,Embase,and the Cochrane Central Register of Controlled Trials (CENTRAL) up to April 01,2017,for randomized controlled trials (RCTs) comparing bisphosphonate treatments in adult KTRs.The primary outcome was BMD change.We executed the tool recommended by the Cochrane Collaboration to evaluate the risk of bias.We performed pairwise meta-analyses using random effects models and network meta-analysis (NMA) using Bayesian models and assessed the quality of evidence.Results:A total of 21 RCTs (1332 participants) comparing 6 bisphosphonate regimens were included.All bisphosphonates showed a significantly increased percentage change in BMD at the lumbar spine