Pandanus amaryllifolius leaf extract increases insulin sensitivity in high-fat diet-induce

Pandanus amaryllifolius leaf extract increases insulin sensitivity in high-fat diet-induced obese

mice

Suphaket Saenthaweesuk;Jarinyaporn Naowaboot;Nuntiya Somparn;

【期刊名称】《亚太热带生物医学杂志：英文版》 【年(卷),期】2016(000)010

【摘要】Objective: To examine the effect of Pandanus amaryllifolius(P. amaryllifolius) leaf extract on the insulin resistance state in obese ICR mice.Methods: Obesity was induced in mice fed with high-fat diet(45% fat) for 12 weeks. After the first six weeks on the diet, the obese mice were administered with the water extract of P. amaryllifolius leaf at 125 and 250 mg/kg/day, respectively for another six weeks. At the5 th week of treatment, oral glucose tolerance test was conducted. After six weeks of treatment, the levels of blood glucose, serum insulin, leptin, adiponectin, and lipid profiles were determined. The liver, muscle and epididymal fat tissues were removed for measuring the biochemical parameters

and

protein

expression,

as

well

as

histological

examination.Results: Six weeks of treatment with P. amaryllifolius led to a significant reduction in the blood glucose level as well as improvement in the insulin resistance. P. amaryllifolius also increased the liver glycogen storage and serum adiponectin and decreased the serum leptin levels. A reduction in the serum and hepatic triglyceride,