NF-κB通路在骨质疏松伴铁蓄积中的潜在作用
王啸;林华;徐又佳
【期刊名称】《中华内分泌代谢杂志》 【年(卷),期】2015(000)002
【摘要】高龄骨质疏松妇女常见铁蛋白水平升高。近来研究表明铁蓄积可能是骨质疏松的独立危险因素。关于铁蓄积引起骨质疏松的研究目前停留在机制探索阶段,其中包括破骨细胞分化中的 NF-κB 通路。本文就 NF-κB 通路与骨质疏松伴铁蓄积的关系作一综述,以期向临床成果转化提供思路。%[Summary] Osteoporosis in elderly women are commonly accompanied by elevated levels of ferritin. Abnormal iron metabolism plays a key role in the progress of osteoporosis. Research on bone metabolic disorders caused by iron accumulation remains at the exploratory stage, including NF-κB pathway in differentiation of osteoclasts. A review on the relationship between NF-κB pathway and osteoporosis induced by iron accumulation is herewith presented, with a view to provide further ideas for transforming the clinical outcomes. 【总页数】3页(192-194)
【关键词】NF-κB;铁代谢;破骨细胞;骨质疏松 【作者】王啸;林华;徐又佳
【作者单位】215004 苏州大学附属第二医院骨科;210008 南京大学医学院附属鼓楼医院骨科;215004 苏州大学附属第二医院骨科 【正文语种】中文