老年慢性心力衰竭患者血尿酸和炎性因子水平变化及相关
性分析
刘锡强;刘海宁;耿庆信;李爱凤;孙金玲
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2011(013)001
【摘要】Objective To investigate the changes of serum uric acid(UA) levels and several inflammatory factors and the relationship between them in elderly patients with congestive heart failure (CHF).Methods Sixty-five elderly patients with CHF and 45 healthy volunteers(control group) were included in this study.In CHF group, 15 were classified as New York Heart Association (NYHA) functional class Ⅱ ,32 as class Ⅲ and 18 as class Ⅳ.The serum UA,plasma creatinine,high-sensitivity C reactive protein (hs-CRP), interleukin 6 (IL-6)and tumor necrosis factor-α (TNF-α) were measured,and echocardiography was performed.The relation between serum UA and these inflammatory factors, the relation between serum UA and cardiac structure and function were analyzed respectively.Results The levels of serum UA,IL-6,hs-CRP and TNF-α were significantly higher in patients with NYHA functional classes Ⅲ - Ⅳ than in controls.There were cpositive correlations between serum UA and TNF-α,IL-6 ,hs-CRP (r = 0.74 ,r = 0.60,r = 0.68,P＜ 0.01) and negative correlation between serum UA and LVEF (r =- 0.73,P ＜ 0.01) in CHF group.Conclusions Serum level of UA is an important prognostic
老年慢性心力衰竭患者血尿酸和炎性因子水平变化及相关性分析
