转录因子Twist在胰腺癌中的表达及在上皮间质转化中的
作用
张同军;薛栋;刘敏;李新军;张成德;成丕光;巩本刚
【期刊名称】《国际外科学杂志》 【年(卷),期】2014(041)006
【摘要】Objective To investigate the relationship of Twist induced epithelial mesenchymal transitions (EMT) during pancreatic carcinoma progression.Methods The expressions of Twist,N-cadherin and Vimentin proteins were tested by immunohistochemistry in 42 cases of pancreatic carcinomas and 26 cases of adjacent paracancerous tissues.Results The positive rates of Twist,N-cadherin and Vimentin in 42 cases of pancreatic carcinomas were 76.2％,59.5％ and 57.1％,respectively.The positive rate of Twist,N-cadherin and Vimentin were all significant between
pancreatic
carcinomas
and
paired
tumor-adjacent
paracancerous tissues (all P ＜0.001).The differences of the expression of Twist,N-cadherin and Vimentin in pancreatic carcinoma of tumor differentiation,TNM stage,neural invasion and lymph node metastasis were significant (all P ＜ 0.05).Significantly positive correlation was found between the expression of Twist and the others (N-cadherin and Vimentin) by using spearman correlation analysis (r =0.506,P =0.001 ; r =0.417,P =0.006).Significantly positive correlation was found between the expression of N-cadherin and Vimentin by using spearman
correlation analysis(r =0.462,P =0.002).Conclusions Twist signaling pathway activation might mediate pancreatic epithelial cells to EMT and then promote pancreatic carcinoma invasion and metastasis.%目的 探讨Twist介导的上皮间质转化在胰腺癌进展中的作用.方法 采用免疫组织化学法检测42例胰腺癌组织中Twist、N-cadherin及Vimentin蛋白的表达,26例癌旁组织作为对照.结果 胰腺癌组织中Twist、N-cadherin及Vimentin蛋白的阳性表达率分别为76.2％、59.5％和57.1％.Twist、N-cadherin 及Vimentin在26例癌组织及配对癌旁组织中的阳性表达率比较,差异均有统计学意义(均P＜0.001);Twist、N-cadherin及Vimentin的表达均与肿瘤分化程度、TNM分期、神经浸润及淋巴结转移明显相关(P＜0.05).经Spearman等级相关性分析,Twist与N-cadherin及Vimentin在胰腺癌组织中的表达均呈正相关(r =0.506,P=0.001;r=0.417,P=0.006);N-cadherin及Vimentin在胰腺癌组织中的表达呈正相关(r=0.462,P=0.002).结论 Twist可能通过诱导胰腺上皮细胞发生上皮间质转化促进胰腺癌侵袭转移. 【总页数】6页(382-386,封3)
【关键词】胰腺肿瘤;Twist转录因子;N-钙黏素;波形蛋白;上皮间质转化;免疫组织化学
【作者】张同军;薛栋;刘敏;李新军;张成德;成丕光;巩本刚
【作者单位】256610滨州,滨州市人民医院肝胆外科;256610滨州,滨州市人民医院肝胆外科;256610滨州,滨州市人民医院干部保健二科;256610滨州,滨州市人民医院病理科;256610滨州,滨州市人民医院肝胆外科;256610滨州,滨州市人民医院肝胆外科;256610滨州,滨州市人民医院肝胆外科
【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_international-journal-surgery_thesis/0201233195353.html 【相关文献】
1.核转录因子-κ B在胰腺癌中的表达及其与上皮细胞间质转化的关系 [J], 石磊; 王世明; 贺杰峰
2.沉默糖原合成激酶3β表达对胰腺癌PANC1细胞生长及上皮间质转化的影响 [J], 宋博; 马洪运; 李森; 邵卓; 宋彬; 郝俊; 程鹏; 金钢
3.MicroRNA-200b在吉西他滨诱导的胰腺癌细胞株MiaPaCa-2上皮间质转化中的作用 [J], 顾玉青; 李占军; 张静静; 高文涛; 钱祝银
4.Hedgehog信号通路调控胰腺癌细胞上皮间质转化的作用机制 [J], 谢昆; 郝昆; 田孝东; 常志刚; 秦昌富; 杨尹默
5.转录因子Sp1在胰腺癌中的表达及其与预后的关系 [J], 陈泉宁; 袁平; 范跃祖; 张景涛
以上内容为文献基本信息，获取文献全文请下载
转录因子Twist在胰腺癌中的表达及在上皮间质转化中的作用
