TGF-β1在SCN5A基因变异所致心源性猝死中调控作用
郝博;宋纬平;午方宇;王小广;罗斌
【期刊名称】《中国法医学杂志》 【年(卷),期】2017(032)003
【摘要】SCN5A基因变异所致心源性猝死发生机制尚不清楚.目前研究显示TGF-β1介导心肌纤维化以及离子通道重构调节机制的异常可能是SCN5A基因变异导致SUNDS发生的主要原因.本文就转化生长因子 β1对SCN5A基因变异所致心源性猝死调控的影响机制研究进展进行综述,以期为心源性猝死法医学研究和实践提供参考.%The mechanism of sudden cardiac death caused by variation in SCN5A is still unclear. Recently, the converging evidences suggest that the dysfunction of regulation mediated by transforming growth factor-β1 in cardiac fibration and reconstruction of cardiac iron channel could be main reason of SUNDS caused by variation of SCN5A. The resent progress of the mechanism of transforming growth factor-β1 in sudden cardiac death caused by variation of SCN5A gene is reviewed in this paper, hoping to provide reference for the research and practice of sudden cardiac death in forensic medicine. 【总页数】4页(290-293)
【关键词】法医病理学;心源性猝死;基因突变;心肌纤维化;离子通道;SCN5A;转化生长因子β1
【作者】郝博;宋纬平;午方宇;王小广;罗斌
【作者单位】中山大学中山医学院法医学系,广东 广州 510080;中山市公安局东
TGF-β1在SCN5A基因变异所致心源性猝死中调控作用
