膦甲酸钠用于巨细胞病毒感染静止期与活动期的效果对比
任吉忠;闵志廉;朱有华
【期刊名称】《中华器官移植杂志》 【年(卷),期】1999(020)001
【摘要】Objective To study the therapeutic effects and side effects of foscarnet in the treatment of active (IgG+ , IgM+ ) and inactive (IgG+ , IgM-
)
cytomegalovirus(CMV)
infection
after
cadaver
renal
transplantation. Methods Forty-one cases of active cytomegalovirus infection and 22 of inactive cytomegalovirus were selected to receive foscarnet treatment. Besides, 10 cases of inactive cytomegalovirus infection served as control group without receiving foscarnet. The usage of foscarnet was 40 mg/kg, iv., 2～3 weeks in the active stage, 50 mg/kg, iv., 3～ 4 weeks in the inactive stage. Results Clinical symptoms of patients in the active stage were controlled, and serologic CMV IgG turned negative.Moreover, no positive infection was found after 3-month follow-up for those who received foscarnet. At the same time, 3 patients in the control group turned into active infection. Only one receiving foscarnet appeared urine volume cutting down temporarily, and the renal function had a reversible change; 2 patients had skin red reaction. Conclusion Foscarnet could control CMV active infection quickly, markedly and firmly, and no recurrence was found during a 3-month follow-up. Foscarnet may protect the inactive patients from
膦甲酸钠用于巨细胞病毒感染静止期与活动期的效果对比
