钩藤碱对帕金森大鼠脑内SOD、DA、MDA表达的调节作
用
王向明;陆学胜
【期刊名称】《中西医结合心脑血管病杂志》 【年(卷),期】2014(000)006
【摘要】Objective To study the regulation of rhynchophylline on the expression levels of dopamine(DA),superoxide dismutase (SOD)and malondialdehyde (MDA)in rats with Parkinson disease (PD).Methods First to extracted rhynchophylline from tradi-tional Chinese medicine uncaria.The second part is to injury PD rat model by Brain positioning injection of 6 OHDA,compare and analyze normal group,model group and rhynchophylline group.Determine DA,SOD in serum and MDA activity in rats’brains by bio-chemical method,and analyze the impact of rhynchophylline on its activity.Results After 30 days drug administration,DA density level of rhynchophylline group was significantly higher than that of model group (P<0.01).At the SOD level,rhynchophylline group was significantly higher than that in model group (P<0.05).Meanwhile the content of MDA compared with the normal group,rhyn-chophylline group and normal group ware close and significantly lower than that of model group (P<0.05).Conclusion Rhyncho-phylline could adj ust SOD,DA and MDA in brains in rats with Parkinson disease (PD).It shows a value of development in Parkinson
钩藤碱对帕金森大鼠脑内SOD、DA、MDA表达的调节作用
